Beckwith-Wiedemann syndrome

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Alteration of chromosome 11p15
Findings:
Macrosomia, rapid growth till late childhood 
Macroglossia
Hemihyperplasia
Medial umbilical wall defects( omphalocele, umbilical hernia)

Increased risk of
Wilms tumor
Hepatoblastoma

Screening:
Abdominal ultrasound and alpha-fetoprotein levels every 3 months from birth to 4 years of age 
4-8 years: abdominal ultrasound every 3 months
8years - adolescence: Renal ultrasound 

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